Digital Microfluidic Instruments

Basic Configuration：

Basicinstrument and software with droplet control capabilities. The range of dropletvolume is 0.1 – 5 μL.

Functional Modules (software modules included):

ModuleI:    Up to 5 chip temperature controllers（4°C – 100°C）;

Module II:   Up to 4 optical excitation wavelengths for illuminatingup to 16 droplets;

ModuleIII:  Optical measurement of up to 16 dropletssimultaneously;

ModuleIV:  On-chip magnetic beads control for DNA、protein、and cell capture.

Advanced Systems (with customized software):

AdvancedSystem I:     Real-time PCR, up to 4xoptical multiplexity;

AdvancedSystem II:    Nucleic acid based sampleprocessing;

AdvancedSystem III:   Immunofluorescencedetection;

AdvancedSystem IV:  Chemiluminescence measurement;

AdvancedSystem V:   Cell separation;

AdvancedSystem VI:  CRISPR based nucleic aciddetection.

Digital Microfluidic Chips:

1. Glasssubstrate – for good temperature control and optical detection;

2.Cover plate – glass or plastic, with sample loading/unloading ports;

3. Transparentelectrodes – optimized for optical measurements;

4. Compatiblewith almost all bio-samples.

Based on electrostatic effects, digital microfluidics (DMF) can perform a set of droplet manipulations – generating, transporting, splitting, merging and mixing, incubation, detection, and storage, which is a complete set of processes of liquid handling in bioanalyses.

In addition to the advantages associated of channel-based microfluidics such as miniaturization, automation and integration, DMF introduces new benefits like universal device/instrument design, digitization, and parallelism, etc. This, in turn, renders better data quality and repeatability.

With reaction volume ranging a few picoliters to tens of microliters, DMF technology offers unprecedented flexibility to bio-analyses, and particularly, to in-vitro diagnostics.

Product application:

Quantitative PCR, nucleic acid sample pretreatment, immunofluorescence detection, chemiluminescence detection, cell sorting, CRISPR based nucleic acid detection, etc.